杨鹏 Peng Yang ORCID 0000-0002-9724-7936 Google Scholar
长聘教授、博士生导师 Professor
E-mail：peng.yang@tongji.edu.cn
Tel：+86-21-65981189
Address： 上海市赤峰路67号实训楼509，同济大学生命科学与技术学院（200092）
67 Chifeng Road, Shixun Building, Room 509, Shanghai, China 200092
教育经历 Education
2006 南京大学 理学学士 Nanjing University B.S.
2011 北京大学 理学博士 Peking University Ph.D.
工作经历 Research Experience
2011-2012 北京生命科学研究所助理研究员 National Institute of Biological Sciences, Beijing, China
2012-2013 美国霍华德休斯医学研究所HHMI博士后 Howard Hughes Medical Institute, US
2013-2017 美国国立卫生研究院NIH博士后 National Institutes of Health, US
2018-今 同济大学生命科学与技术学院 Tongji University, Shanghai, China
学术荣誉及兼职 Honors
2018 “干细胞及转化研究”重点专项首席科学家
2018 上海市启明星青年人才项目
2019 国家海外青年高层次人才
2019 上海海外高层次人才
2019 中国遗传学会表观遗传分会委员
2019 中国细胞学会染色体分会委员
2019 中国遗传学会表观遗传分会委员
2021 上海市曙光计划项目
代表性文章 Publications
Wu Q, Xu J, Zeng J, Wang Y, Yang P*. Exploration of evolutionary mechanisms shaping KZFP and retrotransposon interactions. Science Bulletin 2024; S2095-9273(24)00503-6. doi: 10.1016/j.scib.2024.07.023.(*Corresponding Author)
Wu Q, Fang L, Wang Y*, Yang P*. Unraveling the Role of ZNF506 as a human PBS-Pro-targeting protein for ERVP repression. Nucleic Acids Res.2023; 51(19):10309-10325. doi: 10.1093/nar/gkad731. (*Corresponding Author)
Yang B, Fang L, Gao Q, Xu C, Xu J, Chen Z, Wang Y*, Yang P*.Species-specific KRAB-ZFPs function as repressors of retroviruses by targeting PBS regions. Proc Natl Acad Sci USA. 2022;119(11): e21119415119 (*Corresponding Author)
Guo M, Zhang L, Zhou J, Bi Y, Xu J, Xu C, Kou X, Zhao Y, Li Y, Tu Z, Liu K, Lin J, Yang P*, Gao S*, Wang Y*. Precise temporal regulation of Dux is important for embryo development. Cell Res. 2019;DOI:10.1038/s41422-019-0238-4.[Epub ahead of print](*Corresponding Author)
Patel A*, Yang P*, Tinkham M, Sun M, Wang Y, Hoang D, Wolf G, Horton J, Zhang X, Macfarlan TS, Cheng X. DNA conformation induces adaptable binding by tandem zinc finger proteins. Cell 2018;173(1): 221-233 (*Equal Contribution)
Yang P, Wang Y, Hoang D, Tinkham M, Patel A, Sun M, Wolf G, Baker M, Lai N, Cheng X, Shen J, Macfarlan T. A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568. Science 2017;356(6339): 757-759.
Yang P, Wang Y, Macfarlan T. The role of KRAB-ZFPs in retrotransposon repression and mammalian evolution. Trends in Genetics. 2017;33(11):871-881
Yang P, Wang Y, Chen J, Li H, Kang L, Zhang Y, Chen S, Zhu B, Gao S. Rcor2 is a Subunit of the LSD1 Complex that Regulates ES Cell Property and Substitutes for Sox2 in Reprogramming Somatic Cells to Pluripotency. Stem Cells 2011; 29(5):791-801.
Wang Y, Wu Q, Yang P, Wang C, Liu J, Ding W, Liu W, Bai Y, Yang Y, Wang H, Gao S, Wang X. LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain. Nat Commun. 2016;7:10481
Wolf G, Yang P, Füchtbauer A, Füchtbauer E, Silva A, Park C, Wu W, Nielsen A, Pedersen F, Macfarlan TS. The KRAB zinc finger protein ZFP809 is required to initiate epigenetic silencing of endogenous retroviruses. Genes & Dev. 2015;29(5):538-54.
Yang P, Wu W, Macfarlan TS. Maternal histone variants and their chaperones promote paternal genome activation and boost somatic cell reprogramming. Bioessays. 2015;37(1):52-9.
